Batting first, India piled a mammoth 351/5 in 50 overs.
Among the batters who led the charge were Shubman Gill (85 off 92 balls), Ishan Kishan (77 off 64 balls), skipper Hardik Pandya (70 off 52 balls).
In reply, West Indies crumbled down in 35.3 overs to get bowled out by the Indian attack for just 151.
Shardul Thakur led the Indian pace battery clinching four wickets for 37 runs in 6.3 overs.