Opting to bat first after winning the toss, Kolkata started off poorly losing three wickets within the powerplay.
Rinku Singh (46 off 35 balls) and skipper Nitish Rana (42 off 31 balls) were the top scorers for Kolkata.
Andre Russell contributed 24 off 15 balls while Anukul Roy scored unbeaten 13 off 7 balls towards the end.
Marco Jansen picked 2/24 in four overs for Hyderabad. Two wickets were scalped by T Natarajan for the hosts.