Louisville Metro Police Department said its officers responded to a shooting call outside the Southern Restaurant & Lounge in the city around 3 a.m.
The first victim, an adult man, was pronounced dead at the scene, according to LMPD deputy chief Steve Healey, reported CNN.
The other person died in the hospital.
The injured people were rushed to hospital for treatment.
Four appear to have non-life-threatening injuries and one other victim’s condition is unknown, Healey said.